What has killed the most humans in history?

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What has killed the most humans in history?

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Historical Epidemics and Death Toll

Throughout history, several epidemics and pandemics have caused significant loss of life. Below is a summary of some of the deadliest:

  1. Spanish Flu: estimated between 17 to 100 million deaths.
  2. Plague of Justinian: believed to have claimed 15 to 100 million lives.
  3. Black Death: resulted in approximately 25 to 50 million fatalities.
  4. HIV/AIDS pandemic: accounted for 43 million deaths (as of 2024).
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