Causes of Severe Anemia

Acute Anemia

Anemia is defined as a reduction in the number of red blood cells or hemoglobin levels below the normal range. This condition may arise from a decrease in the production of red blood cells or hemoglobin, or from a rapid loss or breakdown of these cells. Specifically, in men, anemia is indicated by hemoglobin levels falling below 13.5 grams per 100 milliliters, whereas in women, it is below 12 grams per 100 milliliters. Anemia can be classified into acute and chronic types; the acute form manifests rapidly, often accompanied by swift onset of symptoms, while chronic anemia allows the body to adapt to lower oxygen levels, often resulting in minimal symptoms until it becomes severe.

Causes of Acute Anemia

Acute anemia may be indicative of an underlying health condition or result from inadequate nutrition. Given that hemoglobin is iron-dependent, reduced iron levels in the blood pose a significant risk for developing anemia. Below are some of the main factors contributing to this condition:

  • Blood Loss: This includes chronic blood loss from various sources, such as menstruation or hereditary bleeding disorders like hemophilia. Frequent blood donors may also experience difficulties in restoring iron levels.
  • Poor Iron Diet: This poses a risk particularly for vegetarians, as meats are primary sources of iron, especially heme iron, which is more easily absorbed. It is worth noting that a low-iron diet is rarely the sole cause of iron deficiency.
  • Iron Absorption Inhibitors: Certain foods and beverages, like tea, dairy products, coffee, and those rich in vitamin C, can hinder iron absorption. This is particularly concerning for individuals already suffering from iron deficiency.
  • Infections: Certain types of infections, especially parasitic ones affecting the gastrointestinal tract, can lead to anemia.

Risk Factors for Acute Anemia

Several factors may increase the likelihood of iron deficiency and the development of acute anemia, including:

  • Pregnancy: The increased iron requirement during pregnancy makes women more susceptible to anemia, which can impede fetal growth and lead to premature birth.
  • Young Children: Especially during critical growth phases, children under four years old are at higher risk due to rapid growth and limited dietary options.
  • Menstrual Cycle: The loss of iron during menstruation is a common cause of iron deficiency and anemia in women.
  • Surgical Procedures: Major surgeries can sometimes result in acute and severe anemia.
  • Other Nutritional Risk Factors: Conditions like malnutrition, anorexia, vitamin B12 and folic acid deficiencies, and excessive alcohol consumption may increase anemia risk.

Treatment for Anemia

Treatment for anemia typically depends on the underlying cause, as detailed below:

  • Iron Deficiency Anemia: Treatment involves prescribing iron supplements and making dietary adjustments. If blood loss from non-menstrual causes is identified, the source must be addressed, and, in some cases, surgery may be required.
  • Vitamin Deficiency Anemia: This condition can be treated with supplements for folic acid and vitamin B12, along with dietary changes to increase the intake of these vitamins.
  • Anemia of Chronic Disease: Treatment focuses on managing the chronic illness causing the anemia. If symptoms worsen, blood transfusions or synthetic erythropoietin— a hormone that stimulates red blood cell production—may be necessary.
  • Aplastic Anemia: Patients may require blood transfusions or a bone marrow transplant as part of treatment.
  • Bone Marrow Related Anemia: This condition may be treated with specific medications, chemotherapy, or bone marrow transplantation.
  • Hemolytic Anemia: Treatment involves avoiding triggers that cause hemolysis. If medications are suspected, they should be discontinued. In the case of infections, appropriate treatment is necessary, with possible use of immunosuppressive drugs in cases where the immune system attacks red blood cells. Blood transfusions or splenectomy may also be needed.
  • Sickle Cell Anemia: Management focuses on pain relief and minimizing complications through oxygen therapy, pain relievers, and intravenous or oral fluids. Blood transfusions, bone marrow transplants, folic acid supplements, or antibiotics may also be required.
  • Thalassemia: Treatment may involve medication, blood transfusions, bone marrow stem cell transplantation, folic acid supplements, or splenectomy.

Video: Causes of Anemia

Watch the video to learn more about the causes of anemia:

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